Nootropic / Brain Health

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Research Overview

Nootropic Peptides Comparison

A high-level, research-focused comparison of widely discussed cognitive peptides.

Semax Selank Cerebrolysin Dihexa Noopept Pinealon
⚠️
Educational / research use only — not medical advice.
These compounds are not FDA-approved for cognitive enhancement. Long-term human data are limited.
Strong Evidence Moderate Evidence Limited Evidence
Semax ACTH(4–7) Analog
Focus / Attention Neuroprotection Post-Stroke Support
Moderate Evidence

Mechanism

  • ACTH-derived peptide; enhances neuroplasticity pathways.
  • May increase BDNF expression and stress resilience.

Potential Uses

  • Attention, motivation, cognitive support.
  • Stroke recovery (regional clinical use).

Evidence

  • Russian clinical trials; limited Western RCTs.

Safety

  • Not FDA-approved; long-term risks unclear.
Selank Tuftsin Analog
Anxiety / Mood Stress Reduction Cognitive Support
Moderate Evidence

Mechanism

  • Modulates GABAergic signaling.
  • Shows anxiolytic and anti-stress effects.

Potential Uses

  • Anxiety, mood support, cognitive performance under stress.

Evidence

  • Human trials in Eastern Europe; limited global data.

Safety

  • Favorable short-term; long-term data sparse.
Cerebrolysin Neurotrophic Peptide Mix
Stroke Recovery Neurodegeneration Cognitive Rehabilitation
Strong Evidence

Mechanism

  • Mix of neurotrophic peptides supporting neuron repair.
  • Improves synaptic plasticity and neuronal function.

Potential Uses

  • Dementia, stroke, traumatic brain injury research.

Evidence

  • Multiple RCTs show cognitive improvement.

Safety

  • Generally well tolerated; injection only.
Dihexa HGF/c-Met Modulator
Memory Support Synaptogenesis Alzheimer's Research
Limited Evidence

Mechanism

  • Potent synaptogenic activity via HGF signaling.

Potential Uses

  • Neurodegeneration & cognitive decline research.

Evidence

  • Strong rodent data; very limited human evidence.

Safety

  • Theoretical cancer-risk concerns due to growth-factor pathways.
Pinealon Tripeptide Bioregulator
Brain Aging Support Antioxidant Defense Longevity Programs
Limited Evidence

Mechanism

  • EDR tripeptide with antioxidant and neuroprotective effects.

Potential Uses

  • Healthy aging and cognitive resilience.
  • Longevity-oriented peptide rotation programs.

Evidence

  • Mostly Russian research; limited modern trials.

Safety

  • Generally gentle; long-term human data limited.
Noopept Dipeptide-Derived
Memory BDNF/NGF Enhancement Learning
Moderate Evidence

Mechanism

  • Boosts BDNF/NGF; antioxidant and neuroprotective effects.

Potential Uses

  • Learning, memory, mild cognitive impairment research.

Evidence

  • Mainly Russian clinical data; few Western trials.

Safety

  • Generally mild side effects; not FDA-approved.

Nootropic Peptide Comparison Overview

This table provides an educational comparison of commonly discussed nootropic peptides and neurotrophic agents. None are general consumer nootropics, and regulatory status varies by region.

Peptide / Compound Primary Focus Mechanism Highlights Evidence Level Key Risks / Considerations
Dihexa Experimental neuroregeneration Potent HGF/c-Met activator; may stimulate synaptogenesis and connectivity. Preclinical only Theoretical cancer/overgrowth risks; extremely limited human data; very experimental.
Semax Focus, memory & neuroprotection Boosts BDNF, modulates dopamine & cholinergic systems; promotes neuroplasticity. Moderate human data (Russia/Eastern Europe). Possible overstimulation, mood/sleep changes; purity varies in research products.
Selank Calm focus & anxiety support Modulates GABA & serotonin pathways; reduces stress response; nootropic-anxiolytic hybrid. Some human data (Russia/EE), less than Semax. Generally mild; still experimental outside approved regions.
Pinealon Brain aging & antioxidant support Tripeptide bioregulator (EDR); reduces oxidative stress and supports neuron survival. Mostly preclinical + limited Russian bioregulator data. Limited long-term human evidence; purity varies in research-grade products.
Cerebrolysin Stroke, TBI & dementia rehab Neurotrophic peptide mixture; supports neuronal growth, repair & BDNF pathways. Strongest human data (stroke, TBI, cognitive impairment). Requires IM/IV; possible infusion reactions; regulated differently by country.
Summary: Semax, Selank, and Cerebrolysin have the strongest real-world use and data. Pinealon has promising longevity-oriented mechanisms with lighter evidence. Dihexa remains the most potent but also the highest-risk and least studied in humans.

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